Wobbliness (ataxia) after Selamectin (Revolution) in dogs

622 reports to the FDA describe wobbliness (ataxia) in dogs given Selamectin. That is 2.1% of all reports for this medicine, compared with 2.6% across reports for all dog medicines.

622Reports

13%Marked serious

9.6%Recovered

9.8%Died or euthanised

1 daysTypical onset

How soon it started

Same day

97 46%

1–2 days

61 29%

3–7 days

19 9.0%

1–4 weeks

17 8.1%

Over a month

16 7.6%

How the animals did

Recovered

59 9.5%

Recovered with lasting effects

1 0.2%

Still unwell when reported

107 17%

Died

52 8.4%

Euthanised

9 1.4%

Not known

394 63%

Problems reported at the same time

244 39%

148 24%

118 19%

117 19%

87 14%

76 12%

61 9.8%

55 8.8%

Age of the animals

Under 1 year

153

1–3 years

129

4–7 years

126

8–11 years

115

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause wobbliness (ataxia) in dogs?: 622 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

Wobbliness (ataxia) after Ivermectin + Pyrantel (Heartgard Plus) 1,346 reports · 0.9% of its reports
Wobbliness (ataxia) after Milbemycin Oxime + Spinosad (Trifexis) 2,821 reports · 2.2% of its reports
Wobbliness (ataxia) after Moxidectin (ProHeart 6) 1,147 reports · 2.3% of its reports
Wobbliness (ataxia) after Milbemycin Oxime + Praziquantel (Interceptor Plus) 533 reports · 1.7% of its reports
Wobbliness (ataxia) after Milbemycin Oxime (Interceptor) 712 reports · 2.4% of its reports
Wobbliness (ataxia) after Ivermectin (Heartgard) 1,237 reports · 10% of its reports
Wobbliness (ataxia) after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 119 reports · 1.4% of its reports
Wobbliness (ataxia) after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 24 reports · 2.1% of its reports
Wobbliness (ataxia) after Ivermectin + Praziquantel 81 reports · 40% of its reports
Wobbliness (ataxia) after Eprinomectin 30 reports · 29% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with wobbliness (ataxia)