Loss of appetite after Selamectin (Revolution) in dogs

1,842 reports to the FDA describe loss of appetite in dogs given Selamectin. That is 6.3% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

1,842Reports
11%Marked serious
11%Recovered
11%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
284 43%
1–2 days
191 29%
3–7 days
59 9.0%
1–4 weeks
60 9.1%
Over a month
63 9.6%

How the animals did

Recovered
191 10%
Recovered with lasting effects
3 0.2%
Still unwell when reported
287 16%
Died
167 9.1%
Euthanised
36 2.0%
Not known
1,158 63%

Problems reported at the same time

1,102 60%
784 43%
506 27%
224 12%
204 11%
120 6.5%
119 6.5%

Age of the animals

Under 1 year
412
1–3 years
463
4–7 years
450
8–11 years
299
12+ years
161

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause loss of appetite in dogs?
1,842 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Selamectin in dogs · Medicines most reported with loss of appetite