Fever after Selamectin (Revolution) in dogs

322 reports to the FDA describe fever in dogs given Selamectin. That is 1.1% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

322Reports

11%Marked serious

7.1%Recovered

13%Died or euthanised

1 daysTypical onset

How soon it started

Same day

29 36%

1–2 days

27 33%

3–7 days

7 8.6%

1–4 weeks

5 6.2%

Over a month

13 16%

How the animals did

Recovered

22 6.8%

Recovered with lasting effects

1 0.3%

Still unwell when reported

55 17%

Died

38 12%

Euthanised

5 1.6%

Not known

201 62%

Problems reported at the same time

185 57%

120 37%

111 34%

62 19%

52 16%

44 14%

39 12%

35 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause fever in dogs?: 322 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Fever with similar medicines

Fever after Ivermectin + Pyrantel (Heartgard Plus) 597 reports · 0.4% of its reports
Fever after Milbemycin Oxime + Spinosad (Trifexis) 881 reports · 0.7% of its reports
Fever after Moxidectin (ProHeart 6) 1,914 reports · 3.8% of its reports
Fever after Milbemycin Oxime + Praziquantel (Interceptor Plus) 194 reports · 0.6% of its reports
Fever after Milbemycin Oxime (Interceptor) 255 reports · 0.9% of its reports
Fever after Ivermectin (Heartgard) 154 reports · 1.3% of its reports
Fever after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 33 reports · 0.4% of its reports
Fever after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 20 reports · 1.7% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with fever