Vomiting after Selamectin (Revolution) in dogs

The FDA has received 3,074 reports of vomiting in dogs after Selamectin. That is 10% of all reports for this medicine, compared with 28% across reports for all dog medicines, so it is reported less often than average with this medicine.

3,074Reports

7.8%Marked serious

13%Recovered

6.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

490 50%

1–2 days

261 27%

3–7 days

71 7.2%

1–4 weeks

79 8.0%

Over a month

83 8.4%

How the animals did

Recovered

403 13%

Recovered with lasting effects

4 0.1%

Still unwell when reported

359 12%

Died

176 5.7%

Euthanised

19 0.6%

Not known

2,113 69%

Problems reported at the same time

1,071 35%

1,045 34%

784 26%

241 7.8%

194 6.3%

174 5.7%

170 5.5%

146 4.7%

Age of the animals

Under 1 year

731

1–3 years

900

4–7 years

700

8–11 years

428

12+ years

178

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause vomiting in dogs?: 3,074 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Ivermectin + Pyrantel (Heartgard Plus) 20,052 reports · 14% of its reports
Vomiting after Milbemycin Oxime + Spinosad (Trifexis) 75,323 reports · 58% of its reports
Vomiting after Moxidectin (ProHeart 6) 12,413 reports · 25% of its reports
Vomiting after Milbemycin Oxime + Praziquantel (Interceptor Plus) 7,113 reports · 23% of its reports
Vomiting after Milbemycin Oxime (Interceptor) 4,379 reports · 15% of its reports
Vomiting after Ivermectin (Heartgard) 3,182 reports · 26% of its reports
Vomiting after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 3,567 reports · 42% of its reports
Vomiting after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 197 reports · 17% of its reports
Vomiting after Ivermectin + Praziquantel 40 reports · 20% of its reports
Vomiting after Eprinomectin 20 reports · 19% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with vomiting