Vomiting after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs
197 reports to the FDA describe vomiting in dogs given Moxidectin + Pyrantel + Sarolaner. That is 17% of all reports for this medicine, compared with 28% across reports for all dog medicines, so it is reported less often than average with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.
Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin + Pyrantel + Sarolaner cause vomiting in dogs?
- 197 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 27 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Vomiting with similar medicines
- Vomiting after Ivermectin + Pyrantel (Heartgard Plus) 20,052 reports · 14% of its reports
- Vomiting after Milbemycin Oxime + Spinosad (Trifexis) 75,323 reports · 58% of its reports
- Vomiting after Moxidectin (ProHeart 6) 12,413 reports · 25% of its reports
- Vomiting after Milbemycin Oxime + Praziquantel (Interceptor Plus) 7,113 reports · 23% of its reports
- Vomiting after Milbemycin Oxime (Interceptor) 4,379 reports · 15% of its reports
- Vomiting after Selamectin (Revolution) 3,074 reports · 10% of its reports
- Vomiting after Ivermectin (Heartgard) 3,182 reports · 26% of its reports
- Vomiting after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 3,567 reports · 42% of its reports
- Vomiting after Ivermectin + Praziquantel 40 reports · 20% of its reports
- Vomiting after Eprinomectin 20 reports · 19% of its reports
All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with vomiting