Vomiting after Ivermectin + Praziquantel in dogs

40 reports to the FDA describe vomiting in dogs given Ivermectin + Praziquantel. That is 20% of all reports for this medicine, compared with 28% across reports for all dog medicines.

40Reports

38%Marked serious

2.5%Recovered

2.5%Died or euthanised

Same dayTypical onset

How soon it started

Same day

6 55%

1–2 days

5 45%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

0 0.0%

How the animals did

Recovered with lasting effects

1 2.5%

Died

1 2.5%

Not known

38 95%

Problems reported at the same time

Eye or vision problems

19 48%

Wobbliness (ataxia)

16 40%

Accidental exposure

14 35%

Tremors

13 33%

Drooling

8 20%

Loss of appetite

6 15%

Lethargy

6 15%

Labeled drug-species interaction

6 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel cause vomiting in dogs?: 40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Ivermectin + Pyrantel (Heartgard Plus) 20,052 reports · 14% of its reports
Vomiting after Milbemycin Oxime + Spinosad (Trifexis) 75,323 reports · 58% of its reports
Vomiting after Moxidectin (ProHeart 6) 12,413 reports · 25% of its reports
Vomiting after Milbemycin Oxime + Praziquantel (Interceptor Plus) 7,113 reports · 23% of its reports
Vomiting after Milbemycin Oxime (Interceptor) 4,379 reports · 15% of its reports
Vomiting after Selamectin (Revolution) 3,074 reports · 10% of its reports
Vomiting after Ivermectin (Heartgard) 3,182 reports · 26% of its reports
Vomiting after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 3,567 reports · 42% of its reports
Vomiting after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 197 reports · 17% of its reports
Vomiting after Eprinomectin 20 reports · 19% of its reports

All reported side effects of Ivermectin + Praziquantel in dogs · Medicines most reported with vomiting