Vomiting after Moxidectin (ProHeart 6) in dogs

The FDA has received 12,413 reports of vomiting in dogs after Moxidectin. That is 25% of all reports for this medicine, compared with 28% across reports for all dog medicines.

12,413Reports

46%Marked serious

34%Recovered

5.4%Died or euthanised

Same dayTypical onset

How soon it started

Same day

7,621 80%

1–2 days

853 9.0%

3–7 days

341 3.6%

1–4 weeks

282 3.0%

Over a month

428 4.5%

How the animals did

Recovered

4,181 34%

Recovered with lasting effects

9 0.1%

Still unwell when reported

4,741 38%

Died

496 4.0%

Euthanised

178 1.4%

Not known

2,808 23%

Problems reported at the same time

5,055 41%

3,463 28%

3,009 24%

2,898 23%

1,603 13%

1,310 11%

1,113 9.0%

954 7.7%

Age of the animals

Under 1 year

1,229

1–3 years

6,128

4–7 years

3,141

8–11 years

1,336

12+ years

407

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause vomiting in dogs?: 12,413 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Ivermectin + Pyrantel (Heartgard Plus) 20,052 reports · 14% of its reports
Vomiting after Milbemycin Oxime + Spinosad (Trifexis) 75,323 reports · 58% of its reports
Vomiting after Milbemycin Oxime + Praziquantel (Interceptor Plus) 7,113 reports · 23% of its reports
Vomiting after Milbemycin Oxime (Interceptor) 4,379 reports · 15% of its reports
Vomiting after Selamectin (Revolution) 3,074 reports · 10% of its reports
Vomiting after Ivermectin (Heartgard) 3,182 reports · 26% of its reports
Vomiting after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 3,567 reports · 42% of its reports
Vomiting after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 197 reports · 17% of its reports
Vomiting after Ivermectin + Praziquantel 40 reports · 20% of its reports
Vomiting after Eprinomectin 20 reports · 19% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with vomiting