Pale mucous membrane after Moxidectin (ProHeart 6) in dogs

1,957 reports to the FDA describe pale mucous membrane in dogs given Moxidectin. That is 3.9% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,957Reports

70%Marked serious

37%Recovered

9.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

1,396 89%

1–2 days

38 2.4%

3–7 days

38 2.4%

1–4 weeks

47 3.0%

Over a month

51 3.2%

How the animals did

Recovered

723 37%

Still unwell when reported

726 37%

Died

129 6.6%

Euthanised

48 2.5%

Not known

331 17%

Problems reported at the same time

1,507 77%

1,310 67%

755 39%

501 26%

362 18%

337 17%

273 14%

252 13%

Age of the animals

Under 1 year

207

1–3 years

1,186

4–7 years

343

8–11 years

159

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause pale mucous membrane in dogs?: 1,957 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

Pale mucous membrane after Ivermectin + Pyrantel (Heartgard Plus) 282 reports · 0.2% of its reports
Pale mucous membrane after Milbemycin Oxime + Spinosad (Trifexis) 352 reports · 0.3% of its reports
Pale mucous membrane after Milbemycin Oxime + Praziquantel (Interceptor Plus) 140 reports · 0.4% of its reports
Pale mucous membrane after Milbemycin Oxime (Interceptor) 137 reports · 0.5% of its reports
Pale mucous membrane after Selamectin (Revolution) 97 reports · 0.3% of its reports
Pale mucous membrane after Ivermectin (Heartgard) 66 reports · 0.5% of its reports
Pale mucous membrane after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 84 reports · 1.0% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with pale mucous membrane