Pale mucous membrane after Selamectin (Revolution) in dogs

The FDA has received 97 reports of pale mucous membrane in dogs after Selamectin. That is 0.3% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

97Reports

32%Marked serious

12%Recovered

42%Died or euthanised

1 daysTypical onset

How soon it started

Same day

19 49%

1–2 days

4 10%

3–7 days

4 10%

1–4 weeks

5 13%

Over a month

7 18%

How the animals did

Recovered

12 12%

Still unwell when reported

14 14%

Died

39 40%

Euthanised

2 2.1%

Not known

30 31%

Problems reported at the same time

49 51%

41 42%

37 38%

34 35%

28 29%

21 22%

20 21%

20 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause pale mucous membrane in dogs?: 97 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

Pale mucous membrane after Ivermectin + Pyrantel (Heartgard Plus) 282 reports · 0.2% of its reports
Pale mucous membrane after Milbemycin Oxime + Spinosad (Trifexis) 352 reports · 0.3% of its reports
Pale mucous membrane after Moxidectin (ProHeart 6) 1,957 reports · 3.9% of its reports
Pale mucous membrane after Milbemycin Oxime + Praziquantel (Interceptor Plus) 140 reports · 0.4% of its reports
Pale mucous membrane after Milbemycin Oxime (Interceptor) 137 reports · 0.5% of its reports
Pale mucous membrane after Ivermectin (Heartgard) 66 reports · 0.5% of its reports
Pale mucous membrane after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 84 reports · 1.0% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with pale mucous membrane