Kidney problems after Selamectin (Revolution) in dogs

The FDA has received 257 reports of kidney problems in dogs after Selamectin. That is 0.9% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

257Reports

23%Marked serious

2.3%Recovered

37%Died or euthanised

14 daysTypical onset

How soon it started

Same day

19 28%

1–2 days

5 7.5%

3–7 days

5 7.5%

1–4 weeks

12 18%

Over a month

26 39%

How the animals did

Recovered

6 2.3%

Still unwell when reported

48 19%

Died

84 33%

Euthanised

12 4.7%

Not known

107 42%

Problems reported at the same time

107 42%

104 40%

103 40%

99 39%

97 38%

67 26%

49 19%

45 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause kidney problems in dogs?: 257 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Ivermectin + Pyrantel (Heartgard Plus) 619 reports · 0.4% of its reports
Kidney problems after Milbemycin Oxime + Spinosad (Trifexis) 865 reports · 0.7% of its reports
Kidney problems after Moxidectin (ProHeart 6) 840 reports · 1.7% of its reports
Kidney problems after Milbemycin Oxime + Praziquantel (Interceptor Plus) 256 reports · 0.8% of its reports
Kidney problems after Milbemycin Oxime (Interceptor) 243 reports · 0.8% of its reports
Kidney problems after Ivermectin (Heartgard) 187 reports · 1.6% of its reports
Kidney problems after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 37 reports · 0.4% of its reports
Kidney problems after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 26 reports · 2.2% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with kidney problems