Kidney problems after Milbemycin Oxime (Interceptor) in dogs

243 reports to the FDA describe kidney problems in dogs given Milbemycin Oxime. That is 0.8% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

243Reports

36%Marked serious

6.6%Recovered

36%Died or euthanised

12 daysTypical onset

How soon it started

Same day

7 14%

1–2 days

10 20%

3–7 days

5 10%

1–4 weeks

8 16%

Over a month

20 40%

How the animals did

Recovered

15 6.2%

Recovered with lasting effects

1 0.4%

Still unwell when reported

47 19%

Died

64 26%

Euthanised

24 9.9%

Not known

92 38%

Problems reported at the same time

93 38%

93 38%

89 37%

73 30%

68 28%

52 21%

41 17%

38 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause kidney problems in dogs?: 243 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Ivermectin + Pyrantel (Heartgard Plus) 619 reports · 0.4% of its reports
Kidney problems after Milbemycin Oxime + Spinosad (Trifexis) 865 reports · 0.7% of its reports
Kidney problems after Moxidectin (ProHeart 6) 840 reports · 1.7% of its reports
Kidney problems after Milbemycin Oxime + Praziquantel (Interceptor Plus) 256 reports · 0.8% of its reports
Kidney problems after Selamectin (Revolution) 257 reports · 0.9% of its reports
Kidney problems after Ivermectin (Heartgard) 187 reports · 1.6% of its reports
Kidney problems after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 37 reports · 0.4% of its reports
Kidney problems after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 26 reports · 2.2% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with kidney problems