Kidney problems after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs
256 reports to the FDA describe kidney problems in dogs given Milbemycin Oxime + Praziquantel. That is 0.8% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported less often than average with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.
Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Milbemycin Oxime + Praziquantel cause kidney problems in dogs?
- 256 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 52 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Kidney problems with similar medicines
- Kidney problems after Ivermectin + Pyrantel (Heartgard Plus) 619 reports · 0.4% of its reports
- Kidney problems after Milbemycin Oxime + Spinosad (Trifexis) 865 reports · 0.7% of its reports
- Kidney problems after Moxidectin (ProHeart 6) 840 reports · 1.7% of its reports
- Kidney problems after Milbemycin Oxime (Interceptor) 243 reports · 0.8% of its reports
- Kidney problems after Selamectin (Revolution) 257 reports · 0.9% of its reports
- Kidney problems after Ivermectin (Heartgard) 187 reports · 1.6% of its reports
- Kidney problems after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 37 reports · 0.4% of its reports
- Kidney problems after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 26 reports · 2.2% of its reports
All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with kidney problems