Death after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs
920 reports to the FDA describe death in dogs given Milbemycin Oxime + Praziquantel. That is 2.9% of all reports for this medicine, compared with 5.2% across reports for all dog medicines, so it is reported less often than average with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.
Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Milbemycin Oxime + Praziquantel cause death in dogs?
- 920 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 32 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Death with similar medicines
- Death after Ivermectin + Pyrantel (Heartgard Plus) 2,810 reports · 1.9% of its reports
- Death after Milbemycin Oxime + Spinosad (Trifexis) 3,307 reports · 2.5% of its reports
- Death after Moxidectin (ProHeart 6) 2,447 reports · 4.8% of its reports
- Death after Milbemycin Oxime (Interceptor) 1,015 reports · 3.4% of its reports
- Death after Selamectin (Revolution) 785 reports · 2.7% of its reports
- Death after Ivermectin (Heartgard) 609 reports · 5.1% of its reports
- Death after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 125 reports · 1.5% of its reports
- Death after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 60 reports · 5.2% of its reports
All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with death