Milbemycin Oxime + Praziquantel (Interceptor Plus) side effects in dogs
31,526 reports sent to the FDA between 2012 and 2026 involve Milbemycin Oxime + Praziquantel in dogs. The most reported problems were vomiting, diarrhea, lethargy. 11% were marked serious, and where it was recorded, signs eased after stopping the medicine in 75% of cases.
About this medicine
Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.
Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (17,082 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 3,111 reports
- German Shepherd Dog 1,295 reports
- Golden Retriever 1,227 reports
- Australian Shepherd Dog 743 reports
- Pit Bull 592 reports
- Beagle 556 reports
- Chihuahua 429 reports
- Shih Tzu 428 reports
- Yorkshire Terrier 421 reports
- Boxer (german Boxer) 411 reports