Selamectin (Revolution) side effects in dogs
29,390 reports sent to the FDA between 1999 and 2026 involve Selamectin in dogs. The most reported problems were vomiting, lethargy, itching. 7.0% were marked serious, and where it was recorded, signs eased after stopping the medicine in 35% of cases.
About this medicine
Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).
Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (5,955 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 2,608 reports
- German Shepherd Dog 1,146 reports
- Golden Retriever 1,071 reports
- Yorkshire Terrier 929 reports
- Chihuahua 880 reports
- Shih Tzu 734 reports
- Boxer (german Boxer) 555 reports
- Poodle 527 reports
- Dachshund 522 reports
- Beagle 454 reports