Tremors after Selamectin (Revolution) in dogs

The FDA has received 984 reports of tremors in dogs after Selamectin. That is 3.3% of all reports for this medicine, compared with 3.4% across reports for all dog medicines.

984Reports

12%Marked serious

14%Recovered

5.9%Died or euthanised

1 daysTypical onset

How soon it started

Same day

187 50%

1–2 days

98 26%

3–7 days

36 9.6%

1–4 weeks

33 8.8%

Over a month

22 5.9%

How the animals did

Recovered

132 13%

Recovered with lasting effects

2 0.2%

Still unwell when reported

161 16%

Died

49 5.0%

Euthanised

9 0.9%

Not known

631 64%

Problems reported at the same time

351 36%

241 24%

224 23%

148 15%

136 14%

131 13%

109 11%

89 9.0%

Age of the animals

Under 1 year

220

1–3 years

273

4–7 years

217

8–11 years

141

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause tremors in dogs?: 984 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tremors with similar medicines

Tremors after Ivermectin + Pyrantel (Heartgard Plus) 2,169 reports · 1.5% of its reports
Tremors after Milbemycin Oxime + Spinosad (Trifexis) 5,684 reports · 4.4% of its reports
Tremors after Moxidectin (ProHeart 6) 1,208 reports · 2.4% of its reports
Tremors after Milbemycin Oxime + Praziquantel (Interceptor Plus) 766 reports · 2.4% of its reports
Tremors after Milbemycin Oxime (Interceptor) 729 reports · 2.4% of its reports
Tremors after Ivermectin (Heartgard) 959 reports · 8.0% of its reports
Tremors after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 245 reports · 2.9% of its reports
Tremors after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 56 reports · 4.8% of its reports
Tremors after Ivermectin + Praziquantel 61 reports · 30% of its reports
Tremors after Moxidectin + Praziquantel 27 reports · 36% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with tremors