Drooling after Selamectin (Revolution) in dogs

The FDA has received 469 reports of drooling in dogs after Selamectin. That is 1.6% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

469Reports

8.5%Marked serious

9.6%Recovered

6.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

78 60%

1–2 days

29 22%

3–7 days

13 10%

1–4 weeks

5 3.8%

Over a month

5 3.8%

How the animals did

Recovered

44 9.4%

Recovered with lasting effects

1 0.2%

Still unwell when reported

51 11%

Died

25 5.3%

Euthanised

4 0.9%

Not known

344 73%

Problems reported at the same time

168 36%

129 28%

109 23%

98 21%

88 19%

76 16%

62 13%

44 9.4%

Age of the animals

Under 1 year

113

1–3 years

126

4–7 years

115

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause drooling in dogs?: 469 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Ivermectin + Pyrantel (Heartgard Plus) 1,096 reports · 0.7% of its reports
Drooling after Milbemycin Oxime + Spinosad (Trifexis) 1,577 reports · 1.2% of its reports
Drooling after Moxidectin (ProHeart 6) 730 reports · 1.4% of its reports
Drooling after Milbemycin Oxime + Praziquantel (Interceptor Plus) 420 reports · 1.3% of its reports
Drooling after Milbemycin Oxime (Interceptor) 354 reports · 1.2% of its reports
Drooling after Ivermectin (Heartgard) 494 reports · 4.1% of its reports
Drooling after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 166 reports · 1.9% of its reports
Drooling after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 21 reports · 1.8% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with drooling