Drooling after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

420 reports to the FDA describe drooling in dogs given Milbemycin Oxime + Praziquantel. That is 1.3% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

420Reports

32%Marked serious

41%Recovered

6.9%Died or euthanised

1 daysTypical onset

How soon it started

Same day

133 39%

1–2 days

51 15%

3–7 days

24 7.0%

1–4 weeks

32 9.3%

Over a month

105 30%

How the animals did

Recovered

171 41%

Still unwell when reported

145 35%

Died

12 2.9%

Euthanised

17 4.0%

Not known

75 18%

Problems reported at the same time

151 36%

133 32%

85 20%

79 19%

72 17%

63 15%

55 13%

45 11%

Age of the animals

Under 1 year

1–3 years

128

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause drooling in dogs?: 420 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Ivermectin + Pyrantel (Heartgard Plus) 1,096 reports · 0.7% of its reports
Drooling after Milbemycin Oxime + Spinosad (Trifexis) 1,577 reports · 1.2% of its reports
Drooling after Moxidectin (ProHeart 6) 730 reports · 1.4% of its reports
Drooling after Milbemycin Oxime (Interceptor) 354 reports · 1.2% of its reports
Drooling after Selamectin (Revolution) 469 reports · 1.6% of its reports
Drooling after Ivermectin (Heartgard) 494 reports · 4.1% of its reports
Drooling after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 166 reports · 1.9% of its reports
Drooling after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 21 reports · 1.8% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with drooling