Drooling after Moxidectin (ProHeart 6) in dogs

The FDA has received 730 reports of drooling in dogs after Moxidectin. That is 1.4% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

730Reports

54%Marked serious

24%Recovered

10%Died or euthanised

Same dayTypical onset

How soon it started

Same day

409 73%

1–2 days

58 10%

3–7 days

33 5.9%

1–4 weeks

26 4.6%

Over a month

34 6.1%

How the animals did

Recovered

173 24%

Recovered with lasting effects

1 0.1%

Still unwell when reported

328 45%

Died

46 6.3%

Euthanised

28 3.8%

Not known

154 21%

Problems reported at the same time

349 48%

256 35%

239 33%

124 17%

124 17%

122 17%

114 16%

93 13%

Age of the animals

Under 1 year

1–3 years

331

4–7 years

198

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause drooling in dogs?: 730 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Ivermectin + Pyrantel (Heartgard Plus) 1,096 reports · 0.7% of its reports
Drooling after Milbemycin Oxime + Spinosad (Trifexis) 1,577 reports · 1.2% of its reports
Drooling after Milbemycin Oxime + Praziquantel (Interceptor Plus) 420 reports · 1.3% of its reports
Drooling after Milbemycin Oxime (Interceptor) 354 reports · 1.2% of its reports
Drooling after Selamectin (Revolution) 469 reports · 1.6% of its reports
Drooling after Ivermectin (Heartgard) 494 reports · 4.1% of its reports
Drooling after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 166 reports · 1.9% of its reports
Drooling after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 21 reports · 1.8% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with drooling