Drooling after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs

The FDA has received 166 reports of drooling in dogs after Ivermectin + Praziquantel + Pyrantel. That is 1.9% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

166Reports

35%Marked serious

50%Recovered

3.6%Died or euthanised

Same dayTypical onset

How soon it started

Same day

94 77%

1–2 days

13 11%

3–7 days

5 4.1%

1–4 weeks

5 4.1%

Over a month

5 4.1%

How the animals did

Recovered

80 48%

Recovered with lasting effects

3 1.8%

Still unwell when reported

3 1.8%

Died

4 2.4%

Euthanised

2 1.2%

Not known

74 45%

Problems reported at the same time

71 43%

67 40%

38 23%

29 17%

29 17%

28 17%

17 10%

16 9.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel + Pyrantel cause drooling in dogs?: 166 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Ivermectin + Pyrantel (Heartgard Plus) 1,096 reports · 0.7% of its reports
Drooling after Milbemycin Oxime + Spinosad (Trifexis) 1,577 reports · 1.2% of its reports
Drooling after Moxidectin (ProHeart 6) 730 reports · 1.4% of its reports
Drooling after Milbemycin Oxime + Praziquantel (Interceptor Plus) 420 reports · 1.3% of its reports
Drooling after Milbemycin Oxime (Interceptor) 354 reports · 1.2% of its reports
Drooling after Selamectin (Revolution) 469 reports · 1.6% of its reports
Drooling after Ivermectin (Heartgard) 494 reports · 4.1% of its reports
Drooling after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 21 reports · 1.8% of its reports

All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with drooling