Ivermectin + Praziquantel + Pyrantel (Iverhart Max) side effects in dogs
8,523 reports sent to the FDA between 2004 and 2026 involve Ivermectin + Praziquantel + Pyrantel in dogs. The most reported problems were vomiting, lethargy, diarrhea. 12% were marked serious.
About this medicine
Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.
Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (5,283 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 962 reports
- Chihuahua 356 reports
- Yorkshire Terrier 345 reports
- Shih Tzu 307 reports
- German Shepherd Dog 299 reports
- Golden Retriever 261 reports
- Beagle 218 reports
- Dachshund 217 reports
- Maltese 201 reports
- Boxer (german Boxer) 148 reports