Moxidectin + Pyrantel + Sarolaner (Simparica Trio) side effects in dogs
1,160 reports sent to the FDA between 2017 and 2026 involve Moxidectin + Pyrantel + Sarolaner in dogs. The most reported problems were vomiting, lethargy, diarrhea. 23% were marked serious, and where it was recorded, signs eased after stopping the medicine in 72% of cases.
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.
Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (699 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 78 reports
- German Shepherd Dog 57 reports
- Golden Retriever 49 reports
- Australian Shepherd Dog 22 reports
- Yorkshire Terrier 19 reports
- Shih Tzu 19 reports
- Siberian Husky 18 reports
- Pit Bull 17 reports
- French Bulldog 17 reports
- Chihuahua 14 reports