Behaviour change after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs
The FDA has received 55 reports of behaviour change in dogs after Moxidectin + Pyrantel + Sarolaner. That is 4.7% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.
Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin + Pyrantel + Sarolaner cause behaviour change in dogs?
- 55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 54 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Behaviour change with similar medicines
- Behaviour change after Ivermectin + Pyrantel (Heartgard Plus) 1,674 reports · 1.1% of its reports
- Behaviour change after Milbemycin Oxime + Spinosad (Trifexis) 4,099 reports · 3.2% of its reports
- Behaviour change after Moxidectin (ProHeart 6) 688 reports · 1.4% of its reports
- Behaviour change after Milbemycin Oxime + Praziquantel (Interceptor Plus) 852 reports · 2.7% of its reports
- Behaviour change after Milbemycin Oxime (Interceptor) 364 reports · 1.2% of its reports
- Behaviour change after Selamectin (Revolution) 652 reports · 2.2% of its reports
- Behaviour change after Ivermectin (Heartgard) 368 reports · 3.1% of its reports
- Behaviour change after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 146 reports · 1.7% of its reports
All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with behaviour change