Vocalising after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs

29 reports to the FDA describe vocalising in dogs given Moxidectin + Pyrantel + Sarolaner. That is 2.5% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

29Reports

38%Marked serious

41%Recovered

3.4%Died or euthanised

17 daysTypical onset

How soon it started

Same day

4 17%

1–2 days

2 8.7%

3–7 days

1 4.3%

1–4 weeks

6 26%

Over a month

10 43%

How the animals did

Recovered

10 34%

Recovered with lasting effects

2 6.9%

Still unwell when reported

11 38%

Died

1 3.4%

Not known

5 17%

Problems reported at the same time

8 28%

8 28%

8 28%

7 24%

7 24%

7 24%

7 24%

Pain

5 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Pyrantel + Sarolaner cause vocalising in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 17 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Ivermectin + Pyrantel (Heartgard Plus) 694 reports · 0.5% of its reports
Vocalising after Milbemycin Oxime + Spinosad (Trifexis) 1,251 reports · 1.0% of its reports
Vocalising after Moxidectin (ProHeart 6) 390 reports · 0.8% of its reports
Vocalising after Milbemycin Oxime + Praziquantel (Interceptor Plus) 212 reports · 0.7% of its reports
Vocalising after Milbemycin Oxime (Interceptor) 161 reports · 0.5% of its reports
Vocalising after Selamectin (Revolution) 247 reports · 0.8% of its reports
Vocalising after Ivermectin (Heartgard) 173 reports · 1.4% of its reports
Vocalising after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 58 reports · 0.7% of its reports

All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with vocalising