Vocalising after Moxidectin (ProHeart 6) in dogs

The FDA has received 390 reports of vocalising in dogs after Moxidectin. That is 0.8% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

390Reports

55%Marked serious

17%Recovered

20%Died or euthanised

Same dayTypical onset

How soon it started

Same day

181 57%

1–2 days

64 20%

3–7 days

22 7.0%

1–4 weeks

18 5.7%

Over a month

30 9.5%

How the animals did

Recovered

67 17%

Recovered with lasting effects

1 0.3%

Still unwell when reported

182 47%

Died

56 14%

Euthanised

21 5.4%

Not known

63 16%

Problems reported at the same time

138 35%

115 29%

112 29%

75 19%

75 19%

70 18%

69 18%

65 17%

Age of the animals

Under 1 year

1–3 years

146

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause vocalising in dogs?: 390 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Ivermectin + Pyrantel (Heartgard Plus) 694 reports · 0.5% of its reports
Vocalising after Milbemycin Oxime + Spinosad (Trifexis) 1,251 reports · 1.0% of its reports
Vocalising after Milbemycin Oxime + Praziquantel (Interceptor Plus) 212 reports · 0.7% of its reports
Vocalising after Milbemycin Oxime (Interceptor) 161 reports · 0.5% of its reports
Vocalising after Selamectin (Revolution) 247 reports · 0.8% of its reports
Vocalising after Ivermectin (Heartgard) 173 reports · 1.4% of its reports
Vocalising after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 58 reports · 0.7% of its reports
Vocalising after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 29 reports · 2.5% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with vocalising