Pain after Moxidectin (ProHeart 6) in dogs

436 reports to the FDA describe pain in dogs given Moxidectin. That is 0.9% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

436Reports

40%Marked serious

15%Recovered

17%Died or euthanised

1 daysTypical onset

How soon it started

Same day

122 44%

1–2 days

80 29%

3–7 days

30 11%

1–4 weeks

23 8.3%

Over a month

23 8.3%

How the animals did

Recovered

63 14%

Recovered with lasting effects

1 0.2%

Still unwell when reported

164 38%

Died

53 12%

Euthanised

20 4.6%

Not known

135 31%

Problems reported at the same time

195 45%

133 31%

95 22%

76 17%

75 17%

73 17%

72 17%

53 12%

Age of the animals

Under 1 year

1–3 years

117

4–7 years

156

8–11 years

104

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause pain in dogs?: 436 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pain with similar medicines

Pain after Ivermectin + Pyrantel (Heartgard Plus) 330 reports · 0.2% of its reports
Pain after Milbemycin Oxime + Spinosad (Trifexis) 572 reports · 0.4% of its reports
Pain after Milbemycin Oxime + Praziquantel (Interceptor Plus) 129 reports · 0.4% of its reports
Pain after Milbemycin Oxime (Interceptor) 121 reports · 0.4% of its reports
Pain after Selamectin (Revolution) 159 reports · 0.5% of its reports
Pain after Ivermectin (Heartgard) 63 reports · 0.5% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with pain