Pain after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

The FDA has received 129 reports of pain in dogs after Milbemycin Oxime + Praziquantel. That is 0.4% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

129Reports

47%Marked serious

18%Recovered

15%Died or euthanised

16 daysTypical onset

How soon it started

Same day

12 17%

1–2 days

16 22%

3–7 days

5 6.9%

1–4 weeks

6 8.3%

Over a month

33 46%

How the animals did

Recovered

22 17%

Recovered with lasting effects

1 0.8%

Still unwell when reported

37 29%

Died

2 1.6%

Euthanised

17 13%

Not known

50 39%

Problems reported at the same time

50 39%

46 36%

28 22%

27 21%

26 20%

22 17%

21 16%

20 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause pain in dogs?: 129 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 16 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pain with similar medicines

Pain after Ivermectin + Pyrantel (Heartgard Plus) 330 reports · 0.2% of its reports
Pain after Milbemycin Oxime + Spinosad (Trifexis) 572 reports · 0.4% of its reports
Pain after Moxidectin (ProHeart 6) 436 reports · 0.9% of its reports
Pain after Milbemycin Oxime (Interceptor) 121 reports · 0.4% of its reports
Pain after Selamectin (Revolution) 159 reports · 0.5% of its reports
Pain after Ivermectin (Heartgard) 63 reports · 0.5% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with pain