Vocalising after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

The FDA has received 212 reports of vocalising in dogs after Milbemycin Oxime + Praziquantel. That is 0.7% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

212Reports

34%Marked serious

33%Recovered

10%Died or euthanised

5 daysTypical onset

How soon it started

Same day

49 31%

1–2 days

18 11%

3–7 days

15 9.4%

1–4 weeks

21 13%

Over a month

56 35%

How the animals did

Recovered

68 32%

Recovered with lasting effects

1 0.5%

Still unwell when reported

66 31%

Died

13 6.1%

Euthanised

9 4.2%

Not known

55 26%

Problems reported at the same time

60 28%

58 27%

52 25%

47 22%

40 19%

30 14%

30 14%

Restlessness or agitation

29 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause vocalising in dogs?: 212 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Ivermectin + Pyrantel (Heartgard Plus) 694 reports · 0.5% of its reports
Vocalising after Milbemycin Oxime + Spinosad (Trifexis) 1,251 reports · 1.0% of its reports
Vocalising after Moxidectin (ProHeart 6) 390 reports · 0.8% of its reports
Vocalising after Milbemycin Oxime (Interceptor) 161 reports · 0.5% of its reports
Vocalising after Selamectin (Revolution) 247 reports · 0.8% of its reports
Vocalising after Ivermectin (Heartgard) 173 reports · 1.4% of its reports
Vocalising after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 58 reports · 0.7% of its reports
Vocalising after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 29 reports · 2.5% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with vocalising