Vocalising after Selamectin (Revolution) in dogs

The FDA has received 247 reports of vocalising in dogs after Selamectin. That is 0.8% of all reports for this medicine, compared with 1.2% across reports for all dog medicines.

247Reports

19%Marked serious

17%Recovered

11%Died or euthanised

Same dayTypical onset

How soon it started

Same day

67 60%

1–2 days

13 12%

3–7 days

8 7.2%

1–4 weeks

7 6.3%

Over a month

16 14%

How the animals did

Recovered

41 17%

Recovered with lasting effects

2 0.8%

Still unwell when reported

35 14%

Died

23 9.3%

Euthanised

5 2.0%

Not known

141 57%

Problems reported at the same time

Lethargy

75 30%

Behaviour change

53 21%

Restlessness or agitation

52 21%

44 18%

41 17%

39 16%

33 13%

30 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause vocalising in dogs?: 247 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Ivermectin + Pyrantel (Heartgard Plus) 694 reports · 0.5% of its reports
Vocalising after Milbemycin Oxime + Spinosad (Trifexis) 1,251 reports · 1.0% of its reports
Vocalising after Moxidectin (ProHeart 6) 390 reports · 0.8% of its reports
Vocalising after Milbemycin Oxime + Praziquantel (Interceptor Plus) 212 reports · 0.7% of its reports
Vocalising after Milbemycin Oxime (Interceptor) 161 reports · 0.5% of its reports
Vocalising after Ivermectin (Heartgard) 173 reports · 1.4% of its reports
Vocalising after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 58 reports · 0.7% of its reports
Vocalising after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 29 reports · 2.5% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with vocalising