Vocalising after Ivermectin (Heartgard) in dogs

173 reports to the FDA describe vocalising in dogs given Ivermectin. That is 1.4% of all reports for this medicine, compared with 1.2% across reports for all dog medicines.

173Reports

43%Marked serious

35%Recovered

18%Died or euthanised

39 daysTypical onset

How soon it started

Same day

16 18%

1–2 days

7 7.7%

3–7 days

3 3.3%

1–4 weeks

11 12%

Over a month

54 59%

How the animals did

Recovered

48 28%

Recovered with lasting effects

13 7.5%

Still unwell when reported

28 16%

Died

20 12%

Euthanised

12 6.9%

Not known

52 30%

Problems reported at the same time

64 37%

45 26%

37 21%

37 21%

35 20%

34 20%

32 18%

29 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly).

Products with this ingredient include Heartgard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin cause vocalising in dogs?: 173 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 39 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Ivermectin + Pyrantel (Heartgard Plus) 694 reports · 0.5% of its reports
Vocalising after Milbemycin Oxime + Spinosad (Trifexis) 1,251 reports · 1.0% of its reports
Vocalising after Moxidectin (ProHeart 6) 390 reports · 0.8% of its reports
Vocalising after Milbemycin Oxime + Praziquantel (Interceptor Plus) 212 reports · 0.7% of its reports
Vocalising after Milbemycin Oxime (Interceptor) 161 reports · 0.5% of its reports
Vocalising after Selamectin (Revolution) 247 reports · 0.8% of its reports
Vocalising after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 58 reports · 0.7% of its reports
Vocalising after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 29 reports · 2.5% of its reports

All reported side effects of Ivermectin in dogs · Medicines most reported with vocalising