Vocalising after Milbemycin Oxime (Interceptor) in dogs

161 reports to the FDA describe vocalising in dogs given Milbemycin Oxime. That is 0.5% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

161Reports

24%Marked serious

16%Recovered

11%Died or euthanised

2 daysTypical onset

How soon it started

Same day

17 33%

1–2 days

11 22%

3–7 days

5 9.8%

1–4 weeks

4 7.8%

Over a month

14 27%

How the animals did

Recovered

25 16%

Still unwell when reported

25 16%

Died

15 9.3%

Euthanised

2 1.2%

Not known

94 58%

Problems reported at the same time

52 32%

39 24%

37 23%

35 22%

Restlessness or agitation

32 20%

Diarrhea

23 14%

Behaviour change

22 14%

Wobbliness (ataxia)

21 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause vocalising in dogs?: 161 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Ivermectin + Pyrantel (Heartgard Plus) 694 reports · 0.5% of its reports
Vocalising after Milbemycin Oxime + Spinosad (Trifexis) 1,251 reports · 1.0% of its reports
Vocalising after Moxidectin (ProHeart 6) 390 reports · 0.8% of its reports
Vocalising after Milbemycin Oxime + Praziquantel (Interceptor Plus) 212 reports · 0.7% of its reports
Vocalising after Selamectin (Revolution) 247 reports · 0.8% of its reports
Vocalising after Ivermectin (Heartgard) 173 reports · 1.4% of its reports
Vocalising after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 58 reports · 0.7% of its reports
Vocalising after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 29 reports · 2.5% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with vocalising