Vocalising after Ivermectin + Pyrantel (Heartgard Plus) in dogs

694 reports to the FDA describe vocalising in dogs given Ivermectin + Pyrantel. That is 0.5% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

694Reports

50%Marked serious

34%Recovered

10%Died or euthanised

2 daysTypical onset

How soon it started

Same day

142 33%

1–2 days

71 17%

3–7 days

37 8.7%

1–4 weeks

66 16%

Over a month

109 26%

How the animals did

Recovered

223 32%

Recovered with lasting effects

12 1.7%

Still unwell when reported

78 11%

Died

37 5.3%

Euthanised

33 4.8%

Not known

311 45%

Problems reported at the same time

196 28%

149 21%

124 18%

121 17%

119 17%

111 16%

106 15%

103 15%

Age of the animals

Under 1 year

137

1–3 years

192

4–7 years

171

8–11 years

130

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Pyrantel treats roundworms and hookworms.

Products with this combination include Heartgard Plus, Tri-Heart Plus, Iverhart Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Pyrantel cause vocalising in dogs?: 694 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Milbemycin Oxime + Spinosad (Trifexis) 1,251 reports · 1.0% of its reports
Vocalising after Moxidectin (ProHeart 6) 390 reports · 0.8% of its reports
Vocalising after Milbemycin Oxime + Praziquantel (Interceptor Plus) 212 reports · 0.7% of its reports
Vocalising after Milbemycin Oxime (Interceptor) 161 reports · 0.5% of its reports
Vocalising after Selamectin (Revolution) 247 reports · 0.8% of its reports
Vocalising after Ivermectin (Heartgard) 173 reports · 1.4% of its reports
Vocalising after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 58 reports · 0.7% of its reports
Vocalising after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 29 reports · 2.5% of its reports

All reported side effects of Ivermectin + Pyrantel in dogs · Medicines most reported with vocalising