Seizures after Selamectin (Revolution) in dogs

1,272 reports to the FDA describe seizures in dogs given Selamectin. That is 4.3% of all reports for this medicine, compared with 4.4% across reports for all dog medicines.

1,272Reports

34%Marked serious

15%Recovered

10%Died or euthanised

1 daysTypical onset

How soon it started

Same day

193 40%

1–2 days

111 23%

3–7 days

56 12%

1–4 weeks

59 12%

Over a month

66 14%

How the animals did

Recovered

193 15%

Recovered with lasting effects

1 0.1%

Still unwell when reported

178 14%

Died

115 9.0%

Euthanised

13 1.0%

Not known

772 61%

Problems reported at the same time

146 11%

145 11%

131 10%

130 10%

87 6.8%

82 6.4%

69 5.4%

62 4.9%

Age of the animals

Under 1 year

207

1–3 years

327

4–7 years

346

8–11 years

218

12+ years

112

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause seizures in dogs?: 1,272 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Ivermectin + Pyrantel (Heartgard Plus) 3,287 reports · 2.2% of its reports
Seizures after Milbemycin Oxime + Spinosad (Trifexis) 4,483 reports · 3.5% of its reports
Seizures after Moxidectin (ProHeart 6) 2,058 reports · 4.1% of its reports
Seizures after Milbemycin Oxime + Praziquantel (Interceptor Plus) 945 reports · 3.0% of its reports
Seizures after Milbemycin Oxime (Interceptor) 1,089 reports · 3.7% of its reports
Seizures after Ivermectin (Heartgard) 686 reports · 5.7% of its reports
Seizures after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 196 reports · 2.3% of its reports
Seizures after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 90 reports · 7.8% of its reports
Seizures after Ivermectin + Praziquantel 22 reports · 11% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with seizures