Seizures after Ivermectin + Praziquantel in dogs
The FDA has received 22 reports of seizures in dogs after Ivermectin + Praziquantel. That is 11% of all reports for this medicine, compared with 4.4% across reports for all dog medicines, so it is reported unusually often with this medicine.
22Reports
27%Marked serious
4.5%Recovered
18%Died or euthanised
–Typical onset
Sponsored
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Ivermectin + Praziquantel cause seizures in dogs?
- 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Seizures with similar medicines
- Seizures after Ivermectin + Pyrantel (Heartgard Plus) 3,287 reports · 2.2% of its reports
- Seizures after Milbemycin Oxime + Spinosad (Trifexis) 4,483 reports · 3.5% of its reports
- Seizures after Moxidectin (ProHeart 6) 2,058 reports · 4.1% of its reports
- Seizures after Milbemycin Oxime + Praziquantel (Interceptor Plus) 945 reports · 3.0% of its reports
- Seizures after Milbemycin Oxime (Interceptor) 1,089 reports · 3.7% of its reports
- Seizures after Selamectin (Revolution) 1,272 reports · 4.3% of its reports
- Seizures after Ivermectin (Heartgard) 686 reports · 5.7% of its reports
- Seizures after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 196 reports · 2.3% of its reports
- Seizures after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 90 reports · 7.8% of its reports
All reported side effects of Ivermectin + Praziquantel in dogs · Medicines most reported with seizures