Eye or vision problems after Ivermectin + Praziquantel in dogs

95 reports to the FDA describe eye or vision problems in dogs given Ivermectin + Praziquantel. That is 47% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

95Reports

31%Marked serious

4.2%Recovered

4.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

14 74%

1–2 days

5 26%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

0 0.0%

How the animals did

Recovered

4 4.2%

Still unwell when reported

1 1.1%

Died

4 4.2%

Not known

86 91%

Problems reported at the same time

50 53%

33 35%

29 31%

19 20%

Disorientation

9 9.5%

Lethargy

8 8.4%

Drooling

7 7.4%

Seizures

6 6.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel cause eye or vision problems in dogs?: 95 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eye or vision problems with similar medicines

Eye or vision problems after Ivermectin + Pyrantel (Heartgard Plus) 378 reports · 0.3% of its reports
Eye or vision problems after Milbemycin Oxime + Spinosad (Trifexis) 486 reports · 0.4% of its reports
Eye or vision problems after Moxidectin (ProHeart 6) 252 reports · 0.5% of its reports
Eye or vision problems after Milbemycin Oxime + Praziquantel (Interceptor Plus) 70 reports · 0.2% of its reports
Eye or vision problems after Milbemycin Oxime (Interceptor) 88 reports · 0.3% of its reports
Eye or vision problems after Selamectin (Revolution) 126 reports · 0.4% of its reports
Eye or vision problems after Ivermectin (Heartgard) 958 reports · 8.0% of its reports
Eye or vision problems after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 34 reports · 0.4% of its reports
Eye or vision problems after Eprinomectin 81 reports · 77% of its reports

All reported side effects of Ivermectin + Praziquantel in dogs · Medicines most reported with eye or vision problems