Lethargy after Ivermectin + Praziquantel in dogs
The FDA has received 35 reports of lethargy in dogs after Ivermectin + Praziquantel. That is 17% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.
35Reports
17%Marked serious
0.0%Recovered
8.6%Died or euthanised
–Typical onset
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How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Ivermectin + Praziquantel cause lethargy in dogs?
- 35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Lethargy with similar medicines
- Lethargy after Ivermectin + Pyrantel (Heartgard Plus) 7,391 reports · 5.0% of its reports
- Lethargy after Milbemycin Oxime + Spinosad (Trifexis) 19,835 reports · 15% of its reports
- Lethargy after Moxidectin (ProHeart 6) 6,640 reports · 13% of its reports
- Lethargy after Milbemycin Oxime + Praziquantel (Interceptor Plus) 2,407 reports · 7.6% of its reports
- Lethargy after Milbemycin Oxime (Interceptor) 2,528 reports · 8.5% of its reports
- Lethargy after Selamectin (Revolution) 2,964 reports · 10% of its reports
- Lethargy after Ivermectin (Heartgard) 1,488 reports · 12% of its reports
- Lethargy after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 969 reports · 11% of its reports
- Lethargy after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 135 reports · 12% of its reports
- Lethargy after Moxidectin + Praziquantel 21 reports · 28% of its reports
All reported side effects of Ivermectin + Praziquantel in dogs · Medicines most reported with lethargy