Lethargy after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs
The FDA has received 135 reports of lethargy in dogs after Moxidectin + Pyrantel + Sarolaner. That is 12% of all reports for this medicine, compared with 11% across reports for all dog medicines.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.
Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin + Pyrantel + Sarolaner cause lethargy in dogs?
- 135 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 31 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Lethargy with similar medicines
- Lethargy after Ivermectin + Pyrantel (Heartgard Plus) 7,391 reports · 5.0% of its reports
- Lethargy after Milbemycin Oxime + Spinosad (Trifexis) 19,835 reports · 15% of its reports
- Lethargy after Moxidectin (ProHeart 6) 6,640 reports · 13% of its reports
- Lethargy after Milbemycin Oxime + Praziquantel (Interceptor Plus) 2,407 reports · 7.6% of its reports
- Lethargy after Milbemycin Oxime (Interceptor) 2,528 reports · 8.5% of its reports
- Lethargy after Selamectin (Revolution) 2,964 reports · 10% of its reports
- Lethargy after Ivermectin (Heartgard) 1,488 reports · 12% of its reports
- Lethargy after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 969 reports · 11% of its reports
- Lethargy after Ivermectin + Praziquantel 35 reports · 17% of its reports
- Lethargy after Moxidectin + Praziquantel 21 reports · 28% of its reports
All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with lethargy