Diarrhea after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs

125 reports to the FDA describe diarrhea in dogs given Moxidectin + Pyrantel + Sarolaner. That is 11% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

125Reports

36%Marked serious

28%Recovered

11%Died or euthanised

31 daysTypical onset

How soon it started

Same day

15 15%

1–2 days

10 10%

3–7 days

7 7.0%

1–4 weeks

18 18%

Over a month

50 50%

How the animals did

Recovered

33 26%

Recovered with lasting effects

2 1.6%

Still unwell when reported

33 26%

Died

5 4.0%

Euthanised

9 7.2%

Not known

43 34%

Problems reported at the same time

60 48%

38 30%

34 27%

21 17%

14 11%

13 10%

11 8.8%

Dehydration

9 7.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Pyrantel + Sarolaner cause diarrhea in dogs?: 125 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

Diarrhea after Ivermectin + Pyrantel (Heartgard Plus) 9,076 reports · 6.1% of its reports
Diarrhea after Milbemycin Oxime + Spinosad (Trifexis) 7,183 reports · 5.5% of its reports
Diarrhea after Moxidectin (ProHeart 6) 4,291 reports · 8.5% of its reports
Diarrhea after Milbemycin Oxime + Praziquantel (Interceptor Plus) 2,695 reports · 8.5% of its reports
Diarrhea after Milbemycin Oxime (Interceptor) 2,873 reports · 9.7% of its reports
Diarrhea after Selamectin (Revolution) 1,974 reports · 6.7% of its reports
Diarrhea after Ivermectin (Heartgard) 693 reports · 5.8% of its reports
Diarrhea after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 954 reports · 11% of its reports

All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with diarrhea