Diarrhea after Selamectin (Revolution) in dogs

The FDA has received 1,974 reports of diarrhea in dogs after Selamectin. That is 6.7% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

1,974Reports

7.1%Marked serious

10%Recovered

5.6%Died or euthanised

1 daysTypical onset

How soon it started

Same day

239 42%

1–2 days

191 33%

3–7 days

53 9.2%

1–4 weeks

42 7.3%

Over a month

50 8.7%

How the animals did

Recovered

203 10%

Still unwell when reported

220 11%

Died

103 5.2%

Euthanised

7 0.4%

Not known

1,441 73%

Problems reported at the same time

1,071 54%

599 30%

506 26%

136 6.9%

112 5.7%

98 5.0%

88 4.5%

87 4.4%

Age of the animals

Under 1 year

479

1–3 years

557

4–7 years

425

8–11 years

283

12+ years

133

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause diarrhea in dogs?: 1,974 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

Diarrhea after Ivermectin + Pyrantel (Heartgard Plus) 9,076 reports · 6.1% of its reports
Diarrhea after Milbemycin Oxime + Spinosad (Trifexis) 7,183 reports · 5.5% of its reports
Diarrhea after Moxidectin (ProHeart 6) 4,291 reports · 8.5% of its reports
Diarrhea after Milbemycin Oxime + Praziquantel (Interceptor Plus) 2,695 reports · 8.5% of its reports
Diarrhea after Milbemycin Oxime (Interceptor) 2,873 reports · 9.7% of its reports
Diarrhea after Ivermectin (Heartgard) 693 reports · 5.8% of its reports
Diarrhea after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 954 reports · 11% of its reports
Diarrhea after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 125 reports · 11% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with diarrhea