Kidney problems after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs

26 reports to the FDA describe kidney problems in dogs given Moxidectin + Pyrantel + Sarolaner. That is 2.2% of all reports for this medicine, compared with 2.4% across reports for all dog medicines.

26Reports

88%Marked serious

7.7%Recovered

38%Died or euthanised

218 daysTypical onset

How soon it started

Same day

2 9.1%

1–2 days

1 4.5%

3–7 days

0 0.0%

1–4 weeks

2 9.1%

Over a month

17 77%

How the animals did

Recovered

2 7.7%

Still unwell when reported

9 35%

Died

2 7.7%

Euthanised

8 31%

Not known

5 19%

Problems reported at the same time

18 69%

14 54%

14 54%

13 50%

11 42%

10 38%

Dehydration

8 31%

Hyperphosphataemia

8 31%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Pyrantel + Sarolaner cause kidney problems in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 218 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Ivermectin + Pyrantel (Heartgard Plus) 619 reports · 0.4% of its reports
Kidney problems after Milbemycin Oxime + Spinosad (Trifexis) 865 reports · 0.7% of its reports
Kidney problems after Moxidectin (ProHeart 6) 840 reports · 1.7% of its reports
Kidney problems after Milbemycin Oxime + Praziquantel (Interceptor Plus) 256 reports · 0.8% of its reports
Kidney problems after Milbemycin Oxime (Interceptor) 243 reports · 0.8% of its reports
Kidney problems after Selamectin (Revolution) 257 reports · 0.9% of its reports
Kidney problems after Ivermectin (Heartgard) 187 reports · 1.6% of its reports
Kidney problems after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 37 reports · 0.4% of its reports

All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with kidney problems