Kidney problems after Ivermectin + Pyrantel (Heartgard Plus) in dogs

619 reports to the FDA describe kidney problems in dogs given Ivermectin + Pyrantel. That is 0.4% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

619Reports

64%Marked serious

12%Recovered

30%Died or euthanised

13 daysTypical onset

How soon it started

Same day

53 18%

1–2 days

49 16%

3–7 days

32 11%

1–4 weeks

59 20%

Over a month

107 36%

How the animals did

Recovered

59 9.5%

Recovered with lasting effects

15 2.4%

Still unwell when reported

110 18%

Died

90 15%

Euthanised

96 16%

Not known

249 40%

Problems reported at the same time

266 43%

259 42%

229 37%

204 33%

183 30%

131 21%

94 15%

88 14%

Age of the animals

Under 1 year

1–3 years

103

4–7 years

128

8–11 years

163

12+ years

163

About this medicine

Ivermectin prevents heartworm disease (monthly). Pyrantel treats roundworms and hookworms.

Products with this combination include Heartgard Plus, Tri-Heart Plus, Iverhart Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Pyrantel cause kidney problems in dogs?: 619 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 13 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Milbemycin Oxime + Spinosad (Trifexis) 865 reports · 0.7% of its reports
Kidney problems after Moxidectin (ProHeart 6) 840 reports · 1.7% of its reports
Kidney problems after Milbemycin Oxime + Praziquantel (Interceptor Plus) 256 reports · 0.8% of its reports
Kidney problems after Milbemycin Oxime (Interceptor) 243 reports · 0.8% of its reports
Kidney problems after Selamectin (Revolution) 257 reports · 0.9% of its reports
Kidney problems after Ivermectin (Heartgard) 187 reports · 1.6% of its reports
Kidney problems after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 37 reports · 0.4% of its reports
Kidney problems after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 26 reports · 2.2% of its reports

All reported side effects of Ivermectin + Pyrantel in dogs · Medicines most reported with kidney problems