Death after Moxidectin (ProHeart 6) in dogs

2,447 reports to the FDA describe death in dogs given Moxidectin. That is 4.8% of all reports for this medicine, compared with 5.2% across reports for all dog medicines.

2,447Reports

53%Marked serious

0.0%Recovered

99%Died or euthanised

2 daysTypical onset

How soon it started

Same day

442 37%

1–2 days

228 19%

3–7 days

183 15%

1–4 weeks

160 13%

Over a month

180 15%

How the animals did

Still unwell when reported

3 0.1%

Died

1,902 78%

Euthanised

526 21%

Not known

16 0.7%

Problems reported at the same time

832 34%

676 28%

672 27%

496 20%

485 20%

440 18%

376 15%

341 14%

Age of the animals

Under 1 year

1–3 years

493

4–7 years

711

8–11 years

712

12+ years

328

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause death in dogs?: 2,447 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

Death after Ivermectin + Pyrantel (Heartgard Plus) 2,810 reports · 1.9% of its reports
Death after Milbemycin Oxime + Spinosad (Trifexis) 3,307 reports · 2.5% of its reports
Death after Milbemycin Oxime + Praziquantel (Interceptor Plus) 920 reports · 2.9% of its reports
Death after Milbemycin Oxime (Interceptor) 1,015 reports · 3.4% of its reports
Death after Selamectin (Revolution) 785 reports · 2.7% of its reports
Death after Ivermectin (Heartgard) 609 reports · 5.1% of its reports
Death after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 125 reports · 1.5% of its reports
Death after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 60 reports · 5.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with death