Death after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs
The FDA has received 125 reports of death in dogs after Ivermectin + Praziquantel + Pyrantel. That is 1.5% of all reports for this medicine, compared with 5.2% across reports for all dog medicines, so it is reported less often than average with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.
Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Ivermectin + Praziquantel + Pyrantel cause death in dogs?
- 125 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 1 day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Death with similar medicines
- Death after Ivermectin + Pyrantel (Heartgard Plus) 2,810 reports · 1.9% of its reports
- Death after Milbemycin Oxime + Spinosad (Trifexis) 3,307 reports · 2.5% of its reports
- Death after Moxidectin (ProHeart 6) 2,447 reports · 4.8% of its reports
- Death after Milbemycin Oxime + Praziquantel (Interceptor Plus) 920 reports · 2.9% of its reports
- Death after Milbemycin Oxime (Interceptor) 1,015 reports · 3.4% of its reports
- Death after Selamectin (Revolution) 785 reports · 2.7% of its reports
- Death after Ivermectin (Heartgard) 609 reports · 5.1% of its reports
- Death after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 60 reports · 5.2% of its reports
All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with death