Didn't prevent heartworm after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs

319 reports to the FDA describe didn't prevent heartworm in dogs given Moxidectin + Pyrantel + Sarolaner. That is 28% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported unusually often with this medicine.

319Reports

14%Marked serious

0.3%Recovered

0.3%Died or euthanised

305 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

0 0.0%

3–7 days

1 1.0%

1–4 weeks

2 2.1%

Over a month

93 97%

How the animals did

Recovered

1 0.3%

Still unwell when reported

38 12%

Euthanised

1 0.3%

Not known

279 87%

Problems reported at the same time

Weight gain

14 4.4%

Drug dose omission

8 2.5%

Overdose

7 2.2%

Underdose

6 1.9%

Weight loss

6 1.9%

Drug dose administration interval too long

5 1.6%

Cough

5 1.6%

Didn't stop worms

5 1.6%

Age of the animals

Under 1 year

1–3 years

228

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Pyrantel + Sarolaner cause didn't prevent heartworm in dogs?: 319 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 305 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't prevent heartworm with similar medicines

Didn't prevent heartworm after Ivermectin + Pyrantel (Heartgard Plus) 57,581 reports · 39% of its reports
Didn't prevent heartworm after Milbemycin Oxime + Spinosad (Trifexis) 10,801 reports · 8.3% of its reports
Didn't prevent heartworm after Moxidectin (ProHeart 6) 11,529 reports · 23% of its reports
Didn't prevent heartworm after Milbemycin Oxime + Praziquantel (Interceptor Plus) 8,433 reports · 27% of its reports
Didn't prevent heartworm after Milbemycin Oxime (Interceptor) 13,118 reports · 44% of its reports
Didn't prevent heartworm after Selamectin (Revolution) 8,789 reports · 30% of its reports
Didn't prevent heartworm after Ivermectin (Heartgard) 3,385 reports · 28% of its reports
Didn't prevent heartworm after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 1,879 reports · 22% of its reports

All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with didn't prevent heartworm