Cough after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) in dogs

24 reports to the FDA describe cough in dogs given Moxidectin + Pyrantel + Sarolaner. That is 2.1% of all reports for this medicine, compared with 0.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

50%Marked serious

4.2%Recovered

8.3%Died or euthanised

54 daysTypical onset

How soon it started

Same day

2 12%

1–2 days

1 5.9%

3–7 days

0 0.0%

1–4 weeks

3 18%

Over a month

11 65%

How the animals did

Recovered

1 4.2%

Still unwell when reported

9 38%

Died

2 8.3%

Not known

12 50%

Problems reported at the same time

Lethargy

8 33%

Didn't work as expected

6 25%

Nasal discharge

6 25%

Didn't prevent heartworm

5 21%

Loss of appetite

5 21%

Diarrhea

5 21%

Didn't stop worms

4 17%

Abnormal radiograph finding

4 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Pyrantel + Sarolaner cause cough in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 54 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Cough with similar medicines

Cough after Ivermectin + Pyrantel (Heartgard Plus) 727 reports · 0.5% of its reports
Cough after Milbemycin Oxime + Spinosad (Trifexis) 853 reports · 0.7% of its reports
Cough after Moxidectin (ProHeart 6) 434 reports · 0.9% of its reports
Cough after Milbemycin Oxime + Praziquantel (Interceptor Plus) 304 reports · 1.0% of its reports
Cough after Milbemycin Oxime (Interceptor) 193 reports · 0.6% of its reports
Cough after Selamectin (Revolution) 224 reports · 0.8% of its reports
Cough after Ivermectin (Heartgard) 117 reports · 1.0% of its reports
Cough after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 57 reports · 0.7% of its reports

All reported side effects of Moxidectin + Pyrantel + Sarolaner in dogs · Medicines most reported with cough