Cough after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

304 reports to the FDA describe cough in dogs given Milbemycin Oxime + Praziquantel. That is 1.0% of all reports for this medicine, compared with 0.8% across reports for all dog medicines.

304Reports

22%Marked serious

8.6%Recovered

4.3%Died or euthanised

71 daysTypical onset

How soon it started

Same day

22 13%

1–2 days

11 6.3%

3–7 days

10 5.7%

1–4 weeks

30 17%

Over a month

103 59%

How the animals did

Recovered

22 7.2%

Recovered with lasting effects

4 1.3%

Still unwell when reported

88 29%

Died

6 2.0%

Euthanised

7 2.3%

Not known

177 58%

Problems reported at the same time

Didn't prevent heartworm

110 36%

Vomiting

55 18%

Didn't work as expected

46 15%

41 13%

35 12%

27 8.9%

24 7.9%

Abnormal radiograph finding

23 7.6%

Age of the animals

Under 1 year

1–3 years

109

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause cough in dogs?: 304 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 71 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Cough with similar medicines

Cough after Ivermectin + Pyrantel (Heartgard Plus) 727 reports · 0.5% of its reports
Cough after Milbemycin Oxime + Spinosad (Trifexis) 853 reports · 0.7% of its reports
Cough after Moxidectin (ProHeart 6) 434 reports · 0.9% of its reports
Cough after Milbemycin Oxime (Interceptor) 193 reports · 0.6% of its reports
Cough after Selamectin (Revolution) 224 reports · 0.8% of its reports
Cough after Ivermectin (Heartgard) 117 reports · 1.0% of its reports
Cough after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 57 reports · 0.7% of its reports
Cough after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 24 reports · 2.1% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with cough