Cough after Moxidectin (ProHeart 6) in dogs

434 reports to the FDA describe cough in dogs given Moxidectin. That is 0.9% of all reports for this medicine, compared with 0.8% across reports for all dog medicines.

434Reports

41%Marked serious

9.0%Recovered

23%Died or euthanised

2 daysTypical onset

How soon it started

Same day

93 35%

1–2 days

54 20%

3–7 days

33 12%

1–4 weeks

34 13%

Over a month

51 19%

How the animals did

Recovered

38 8.8%

Recovered with lasting effects

1 0.2%

Still unwell when reported

180 41%

Died

78 18%

Euthanised

21 4.8%

Not known

116 27%

Problems reported at the same time

139 32%

119 27%

101 23%

100 23%

94 22%

Abnormal radiograph finding

71 16%

Liver problems

55 13%

Swelling

54 12%

Age of the animals

Under 1 year

1–3 years

138

4–7 years

109

8–11 years

109

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause cough in dogs?: 434 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Cough with similar medicines

Cough after Ivermectin + Pyrantel (Heartgard Plus) 727 reports · 0.5% of its reports
Cough after Milbemycin Oxime + Spinosad (Trifexis) 853 reports · 0.7% of its reports
Cough after Milbemycin Oxime + Praziquantel (Interceptor Plus) 304 reports · 1.0% of its reports
Cough after Milbemycin Oxime (Interceptor) 193 reports · 0.6% of its reports
Cough after Selamectin (Revolution) 224 reports · 0.8% of its reports
Cough after Ivermectin (Heartgard) 117 reports · 1.0% of its reports
Cough after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 57 reports · 0.7% of its reports
Cough after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 24 reports · 2.1% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with cough