Abnormal radiograph finding after Moxidectin (ProHeart 6) in dogs

The FDA has received 498 reports of abnormal radiograph finding in dogs after Moxidectin. That is 1.0% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

498Reports

44%Marked serious

3.2%Recovered

35%Died or euthanised

2 daysTypical onset

How soon it started

Same day

80 29%

1–2 days

58 21%

3–7 days

48 18%

1–4 weeks

34 13%

Over a month

52 19%

How the animals did

Recovered

15 3.0%

Recovered with lasting effects

1 0.2%

Still unwell when reported

177 36%

Died

108 22%

Euthanised

67 13%

Not known

130 26%

Problems reported at the same time

214 43%

194 39%

191 38%

178 36%

171 34%

154 31%

108 22%

95 19%

Age of the animals

Under 1 year

1–3 years

111

4–7 years

157

8–11 years

143

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause abnormal radiograph finding in dogs?: 498 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal radiograph finding with similar medicines

Abnormal radiograph finding after Ivermectin + Pyrantel (Heartgard Plus) 505 reports · 0.3% of its reports
Abnormal radiograph finding after Milbemycin Oxime + Spinosad (Trifexis) 630 reports · 0.5% of its reports
Abnormal radiograph finding after Milbemycin Oxime + Praziquantel (Interceptor Plus) 164 reports · 0.5% of its reports
Abnormal radiograph finding after Milbemycin Oxime (Interceptor) 138 reports · 0.5% of its reports
Abnormal radiograph finding after Selamectin (Revolution) 149 reports · 0.5% of its reports
Abnormal radiograph finding after Ivermectin (Heartgard) 103 reports · 0.9% of its reports
Abnormal radiograph finding after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 52 reports · 0.6% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with abnormal radiograph finding