Abnormal radiograph finding after Milbemycin Oxime (Interceptor) in dogs

138 reports to the FDA describe abnormal radiograph finding in dogs given Milbemycin Oxime. That is 0.5% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported less often than average with this medicine.

138Reports

34%Marked serious

6.5%Recovered

30%Died or euthanised

15 daysTypical onset

How soon it started

Same day

3 9.4%

1–2 days

3 9.4%

3–7 days

4 13%

1–4 weeks

9 28%

Over a month

13 41%

How the animals did

Recovered

7 5.1%

Recovered with lasting effects

2 1.4%

Still unwell when reported

24 17%

Died

31 22%

Euthanised

11 8.0%

Not known

63 46%

Problems reported at the same time

60 43%

57 41%

47 34%

44 32%

41 30%

32 23%

31 22%

27 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause abnormal radiograph finding in dogs?: 138 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 15 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal radiograph finding with similar medicines

Abnormal radiograph finding after Ivermectin + Pyrantel (Heartgard Plus) 505 reports · 0.3% of its reports
Abnormal radiograph finding after Milbemycin Oxime + Spinosad (Trifexis) 630 reports · 0.5% of its reports
Abnormal radiograph finding after Moxidectin (ProHeart 6) 498 reports · 1.0% of its reports
Abnormal radiograph finding after Milbemycin Oxime + Praziquantel (Interceptor Plus) 164 reports · 0.5% of its reports
Abnormal radiograph finding after Selamectin (Revolution) 149 reports · 0.5% of its reports
Abnormal radiograph finding after Ivermectin (Heartgard) 103 reports · 0.9% of its reports
Abnormal radiograph finding after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 52 reports · 0.6% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with abnormal radiograph finding