Abnormal radiograph finding after Selamectin (Revolution) in dogs

The FDA has received 149 reports of abnormal radiograph finding in dogs after Selamectin. That is 0.5% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported less often than average with this medicine.

149Reports

24%Marked serious

4.7%Recovered

26%Died or euthanised

3 daysTypical onset

How soon it started

Same day

12 24%

1–2 days

11 22%

3–7 days

5 10%

1–4 weeks

3 6.1%

Over a month

18 37%

How the animals did

Recovered

7 4.7%

Still unwell when reported

39 26%

Died

29 19%

Euthanised

10 6.7%

Not known

64 43%

Problems reported at the same time

Lethargy

48 32%

Loss of appetite

47 32%

Vomiting

43 29%

Didn't prevent heartworm

41 28%

40 27%

37 25%

31 21%

28 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause abnormal radiograph finding in dogs?: 149 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal radiograph finding with similar medicines

Abnormal radiograph finding after Ivermectin + Pyrantel (Heartgard Plus) 505 reports · 0.3% of its reports
Abnormal radiograph finding after Milbemycin Oxime + Spinosad (Trifexis) 630 reports · 0.5% of its reports
Abnormal radiograph finding after Moxidectin (ProHeart 6) 498 reports · 1.0% of its reports
Abnormal radiograph finding after Milbemycin Oxime + Praziquantel (Interceptor Plus) 164 reports · 0.5% of its reports
Abnormal radiograph finding after Milbemycin Oxime (Interceptor) 138 reports · 0.5% of its reports
Abnormal radiograph finding after Ivermectin (Heartgard) 103 reports · 0.9% of its reports
Abnormal radiograph finding after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 52 reports · 0.6% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with abnormal radiograph finding